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DNA Testing For Genetic Relational Database

DNA Analysis at King’s College London carries out the DNA testing for the Donor Conceived Register.

The service details of the agreement between the DCR and DNA Analysis at King’s state:

DNA Analysis at King’s, King’s College London, agrees to provide a quality laboratory service accredited to ISO17025 for the clients referred to it by the Donor Conceived Register (DCR).

The following terms have been agreed:

  • DCR will provide DNA Analysis at King’s with the full names, dates of birth and contact information of all clients from whom a sample will be sent
  • DNA Analysis at King’s will inform DCR by e-mail when samples have been received
  • DNA Analysis at King’s will offer to sample DCR registrants within our clinic by appointment
  • DNA Analysis at King’s will inform DCR within 72 hours of receipt of the samples if they do not meet the following requirements:
  1. The sample shall arrive intact and in an appropriate leak-proof container
  2. The sample shall have been shipped promptly and be an appropriate one for the agreed analysis
  3. The sample shall be labelled with a minimum of one full fore-name and surname
  4. The sample shall be accompanied by the appropriate written consent for the agreed analysis
  5. The sample shall be accompanied by paperwork detailing the name, gender, date of birth, racial origin and authenticated photograph of the sampled individual
  • DNA Analysis at King’s will log the arrival of all samples received in the Sample Log Book where each will be given a unique sample number
  • DNA Analysis at King’s will attempt to analyse any sample of human origin and will inform DCR if they experience any problems with the analytical process
  • All analyses will be subject to a second independent test from the original sample, normally undertaken by a different scientist
  • DNA tests used will be short tandem repeat (STR) tests. Around 36 markers will be used (ESS and HDPlex)
  • Testing will include an appropriate statistical analysis, taking account of linkage between markers, and the results provided as a likelihood ratio. A statement will be provided as to the strength of the evidence
  • Before reports are released each and every record and transfer of data or other information will be checked and recorded as such. No reports will be signed before all checks have been undertaken
  • One original copy of their genetic results will be provided to each client, but not to the DCR
  • A report will also be provided to each client with a copy to the DCR. This report will indicate whether any significant relationships have been revealed (LR >10) after testing, and will comment on any equivocal relationships and what attempts are being undertaken to resolve these. Linked individuals will only be identified by a unique number, although information about the identity of the linked donor will be provided to the DCR
  • Reporting time: approximately 5 to 6 weeks
  • DNA Analysis at King’s expects that DCR will make contact with any linked individuals if the identity of one is to be revealed to another (see also ‘in case of match’)
  • After the initial bulk of comparisons anticipated in the early stages of the project, all new samples will be searched across the entire database and dealt with in the same way
  • DNA Analysis at King’s will provide written or verbal explanations to the client, or the DCR, of any results as requested at no additional cost
  • DNA Analysis at King’s will not enter into any communication with any individuals other than those tested unless authorised to do so. Appropriate authorities will require written consent from the person being tested and sufficient information to confirm identity
  • All communications relating to an individual (or individual and known family member) will be preserved within a single case file
  • DNA Analysis at King’s will retain all case files, laboratory records and a portion of the sample provided for a minimum of seven years (or longer as agreed) unless we receive written request from an individual to destroy their samples and/or records and will transfer the same to DCR at their request
  • DNA Analysis at King’s will not use any portions of the samples provided for any other purpose
  • DNA Analysis at King’s will store all records confidentially and in accordance with the UK Data Protection Act
  • DNA Analysis at King’s will not refer any work to other laboratories
  • DNA Analysis at King’s will undertake repeat or additional testing on any samples as required at no additional charge
  • DNA Analysis at King’s participates in the following External Quality Assessment Programmes for the examinations it carries out:
    • International Society for Forensic Genetics – The English Speaking Working Group Relationship Testing Workshop Interlaboratory Comparison (annual)
    • College of American Pathologists (CAP) and American Association of Blood Banks Proficiency Relationship Test (three times a year)
    • The results of these programmes are available for inspection by DCR at any time.
  • DNA Analysis at King’s has an internal quality programme in place to ensure that the results on samples are valid. In addition to the internal quality measures described above in relation to each sample the following measures are also used:
  1. Batch control testing
  2. Run control testing
  3. DNA amplification control testing
  4. Internal blind testing
  • DNA Analysis at King’s is a UKAS accredited testing laboratory No: 7850 (ISO17025)

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